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Lysosomal thiol reductase

Web1 dec. 2015 · The lysosomal thiol reductase GILT catalyzes the reduction of disulfide bonds in the endocytic compartments. Facilitating antigen presentation is the most established function for GILT. Emerging roles for lysosomal GILT include modulating cysteine protease stability and activity, controlling the cellular redox state and redox … Web1 ian. 2000 · Cytosolic reduction is mediated enzymatically by thioredoxin, but the mechanism of lysosomal reduction is unknown. We describe here a lysosomal thiol reductase optimally active at low pH and capable of catalyzing disulfide bond reduction both in vivo and in vitro. The active site, determined by mutagenesis, consists of a pair of …

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Web4 apr. 2008 · Gamma interferon-inducible thiol reductase (GILT) is an enzyme involved in the initial steps of antigen processing and presentation. Recently we have shown that GILT is also expressed in mouse T cells, where it exerts an inhibitory role on T cell activation. Weblysosomal thiol reductase (GILT), constitutively ex-pressed in antigen-presenting cells, that catalyzes disul-fide bond reduction both in vitro and in vivo and is optimally active at … tarif j\\u0026t cargo per kg https://ilohnes.com

NGS Evaluation of Colorectal Cancer Reveals Interferon Gamma …

WebInterferon-γ-inducible lysosomal thiol reductase (GILT) has been discovered in many species [ 1, 2 ]. The precursor of GILT is a soluble glycoprotein, which enters the lysosome by interacting with the mannose-6-phosphate receptor and is transformed into the mature form by cleavage at the N- and C-termini [ 3, 4 ]. Web4 iul. 2024 · Lysosomal reductase Gamma Interferon-Inducible Thiol Reductase (GILT) is the only identified lysosomal reductase that controls more than 11 lysosomal … Web1 ian. 1987 · Thiol-dependent thiosulfate reductases occur in both prokaryotic and eukaryotic organisms of various phyla. These enzymes use electrons from thiols to … tarif jtr jne adalah

Diverse cellular and organismal functions of the lysosomal thiol ...

Category:杭州师范大学医学部基础医学院

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Lysosomal thiol reductase

336503 - Gene Resultifi30 IFI30 lysosomal thiol reductase

WebGamma-interferon-inducible lysosomal thiol reductase (GILT) is related not only to antigen presentation but also to bacteria invasions. But the systematic studies are … WebThese studies demonstrate that the thiol reductase activity of GILT is its essential function in MHC class II-restricted Ag processing. The Journal of Immunology, 2006, 177: 8569–8577.

Lysosomal thiol reductase

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Web1 nov. 2010 · The interferon-γ-inducible lysosomal thiol reductase enzymes (GILT) have been shown to play an important role in the processing of exogenous antigens by catalyzing disulfide bond reduction, that... Web13 rânduri · 5 apr. 2011 · Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete ...

Web1 ian. 2015 · 1. Introduction. Gamma-interferon-inducible lysosomal thiol reductase (GILT) was originally discovered as a novel γ-Interferon-inducible protein, namely IP-30, in the human monocytic cell line U937 .It is constitutively expressed in most antigen presenting cells (APCs), including monocytes/macrophages, B cells and bone marrow-derived … WebMaric, M., Barjaktarevic, I., Bogunovic, B., Stojakovic, M., Maric, C., & Vukmanovic, S. (2009). Cutting Edge: Developmental Up-Regulation of IFN- -Inducible ...

WebThe work presented here evaluates the control of redox sensitive processes involved in phagosomal protein degradation which include the activities of cysteine cathepsins and gamma-interferon-inducible lysosomal thiol reductase (GILT). The catalytic mechanisms of these enzymes are dependent on reduced active site thiol (SH) groups making them … WebHoney, K., Duff, M., Beers, C., Brissette, W. H., Elliott, E. A., Peters, C., … Rudensky, A. (2001). Cathepsin S Regulates the Expression of Cathepsin L and the ...

Web20 dec. 2016 · Therefore, IP30 was given a new descriptive name, gamma-interferon-inducible lysosomal thiol reductase (GILT). GILT is the only known thiol reductase in …

WebAntigen presentation is a key determinant of T-cell responses. Gamma-interferon-inducible lysosomal thiol reductase (GILT) is critical for MHC class II-restricted presentation of … tarif jtr jakarta surabayaWeb27 dec. 2024 · Interferon gamma-induced lysosomal thiol reductase (GILT) is abundantly expressed in antigen-presenting cells and participates in the treatment and presentation of antigens by major ... tarif jtr jakarta bandungWeb4 apr. 2008 · Gamma interferon-inducible thiol reductase (GILT) is an enzyme involved in the initial steps of antigen processing and presentation. Recently we have shown that … tarif j&t cargo surabaya jakartahttp://bms.hznu.edu.cn/c/2024-04-10/2825540.shtml 飢 へんWebWe recently identified agamma-interferon-induciblelysosomal thiol reductase (GILT), constitutively expressed in antigen-presenting cells, that catalyzes disulfide bond reduction both in vitro andin vivo and is optimally active at acidic pH. GILT is synthesized as a 35-kDa precursor, and following delivery to major histocompatibility complex (MHC) class II … tarif j&t cargo per 10 kgWeb10 apr. 2024 · Jian Feng Li, Wang ZG, Liu HZ, Zhao YL, Zhang JX, Zhang SQ, Liu JP ， Identification of interferon-γ-inducible-lysosomal thiol reductase (GILT) gene in goldfish (Carassius auratus) and its immune response to LPS challenge ， Fish & Shellfish Immunology ， 2015 ， 42 ， 465-472. 6. tarif jumper l4h2Web8 dec. 2024 · The lysosomal thiol reductase GILT expressed by antigen-presenting cells has diverse cellular and organismal functions. (Review) this review discusses recent … 飢え死にすべかりければ 現代語訳