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Multidrug and toxin extrusion transporter

Web26 apr. 2012 · organic cation transporter 3, multidrug and toxin extrusion transporter 1, placenta, pregnancy, pharmacokinetics, MPP +. Topic: fetus maternal-fetal exchange membrane transport proteins mothers toxins kidney pharmacokinetics placenta rats fetoplacental circulation maternal circulation organic cation transporter 3 Issue Section: … Web2 sept. 2015 · A combinatorial pharmacophore (CP) model for Multidrug and toxin extrusion 1 (MATE1/SLC47A1) inhibitors was developed based on a data set including …

Associations of genetic polymorphisms of the transporters organic ...

Multi-antimicrobial extrusion protein (MATE) also known as multidrug and toxin extrusion or multidrug and toxic compound extrusion is a family of proteins which function as drug/sodium or proton antiporters. Web1 mar. 2009 · Recently, a multidrug and toxin extrusion (MATE) transporter protein family was identified, assigned as the SLC 47 family ( 12, 13 ). The SLC47A1 gene, with gene location 17p11.2, encodes the MATE1 transporter. Metformin is one of the substrates of this transporter ( 14 ). hawaiian asian https://ilohnes.com

Structural biology of the multidrug and toxic compound extrusion ...

Web1 feb. 2024 · Multidrug and toxin extrusion (MATE) transporters are expressed on the luminal membrane of renal proximal tubule cells and extrude their substrates into the … Weband the multidrug and toxin extrusion (MATE) transporters. MATE belongs to the SLC47 transporter family consisting of only two members, MATE1 and MATE2-K. MATE2-K WebMultidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 … hawaiian artesian water

Interaction of human multidrug and toxin extrusion 1 (MATE1 ...

Category:Efavirenz reduces renal excretion of lamivudine in rats by ... - PLOS

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Multidrug and toxin extrusion transporter

Structural biology of the multidrug and toxic compound extrusion ...

Web30 iun. 2024 · Both uptake and efflux drug transporters are involved in kidney toxicity of some drugs. Source: reprinted from basit, radi, vaidya, karasu, prasad, ©2024. MATE, … WebSeems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. Pfam Domain Function MatE ( PF01554) Transmembrane Regions

Multidrug and toxin extrusion transporter

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Web1. Multidrug and toxic compound extrusion (MATE)-type transporters, which were first identified as a bacterial drug transporter family, are present in almost all prokaryotes … WebAmong the SLC47 family, multidrug and toxin extrusion protein 1, or MATE1 (SLC47A1), an organic cation/proton exchanger, mostly expressed in hepatocytes and renal …

Web15 ian. 2024 · These results suggest that the combination of metformin and berberine induced a pharmacokinetic interaction by cooperatively inhibiting OCT and MATE1 … Web1 feb. 2014 · Human multidrug and toxic compounds extrusion transporter 1 (hMATE1/SLC47A1) is a H (+)-coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at...

Web1 aug. 2016 · Multidrug and toxin extrusion transporters (MATEs) have a determining influence on the pharmacokinetic profiles of many drugs and are involved in several clinical drug-drug interactions (DDIs).

Web1 ian. 2024 · Multidrug and toxin extrusion proteins mediate cellular transport of cadmium Cadmium (Cd) is an environmentally prevalent toxicant posing increasing risk …

Web13 sept. 2012 · Multidrug and toxin extrusion (MATE) proteins as transporters of antimicrobial drugs Authors: Anne T Nies Katja Damme Elke Schaeffeler Matthias Schwab Abstract Introduction: Antimicrobial... hawaiian asian marketWeb29 aug. 2014 · So far, the number of polymorphisms in SLC22A1, SLC22A2, and SLC47A1 genes coding for organic cation transporter 1 (OCT1), OCT2, and multidrug and toxin extrusion transporter 1 (MATE1) metformin ... hawaiian australiaWeb2 sept. 2015 · Ito, S. et al. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the ... hawaiian baby girl jumpsuitWeb27 ian. 2024 · Members of multidrug and toxin extrusion (MATE) transporters are imparted in the secondary metabolites transportation. ... Export of salicylic acid from the … hawaiian backdropWebMeth excretion and organic cation transporters (OCTs) and multidrug and toxin extrusion (MATE) transporters. ... organic anion transporter (OAT) or MATE. Some of … hawaiian artists kauaiWeb3.1.3 Multidrug and toxin extrusion protein 2 (MATE2) MATE2 is a primarily of organic cations and act as a poly-specific efflux transporters for diverse substrates. It is an important player for renal excretion of exogenous and endogenous organic cations, mainly for … hawaiian art designWebMatsuzaki T, Morisaki T, Sugimoto W, et al. Altered pharmacokinetics of cationic drugs caused by down-regulation of renal rat organic cation transporter 2 (Slc22a2) and rat … hawaiian bagel