Web26 apr. 2012 · organic cation transporter 3, multidrug and toxin extrusion transporter 1, placenta, pregnancy, pharmacokinetics, MPP +. Topic: fetus maternal-fetal exchange membrane transport proteins mothers toxins kidney pharmacokinetics placenta rats fetoplacental circulation maternal circulation organic cation transporter 3 Issue Section: … Web2 sept. 2015 · A combinatorial pharmacophore (CP) model for Multidrug and toxin extrusion 1 (MATE1/SLC47A1) inhibitors was developed based on a data set including …
Associations of genetic polymorphisms of the transporters organic ...
Multi-antimicrobial extrusion protein (MATE) also known as multidrug and toxin extrusion or multidrug and toxic compound extrusion is a family of proteins which function as drug/sodium or proton antiporters. Web1 mar. 2009 · Recently, a multidrug and toxin extrusion (MATE) transporter protein family was identified, assigned as the SLC 47 family ( 12, 13 ). The SLC47A1 gene, with gene location 17p11.2, encodes the MATE1 transporter. Metformin is one of the substrates of this transporter ( 14 ). hawaiian asian
Structural biology of the multidrug and toxic compound extrusion ...
Web1 feb. 2024 · Multidrug and toxin extrusion (MATE) transporters are expressed on the luminal membrane of renal proximal tubule cells and extrude their substrates into the … Weband the multidrug and toxin extrusion (MATE) transporters. MATE belongs to the SLC47 transporter family consisting of only two members, MATE1 and MATE2-K. MATE2-K WebMultidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 … hawaiian artesian water