Phkg2 ferroptosis
WebbFerroptosis, a newly discovered iron-dependent form of cell death, contributes to various pathologies; however, the prognostic value of ferroptosis-related genes (FRGs) in cervical cancer (CC) remains unclear. Herein, we identified 15 differentially expressed FRGs based on data from The Cancer Genome Atlas database. Webb28 juni 2024 · Ferroptosis is a new type of iron-dependent programmed cell death. ... proteomic sequencing analysis and OP-B administration showed the up-regulation of AURKA and down-regulation of PHKG2 and SLC7A5 in the 12-gene signature, indicating that OP-B induced NSCLC ferroptosis. Determination of malondialdehyde (MDA), …
Phkg2 ferroptosis
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Webb26 jan. 2024 · Yang et al. observed that PUFA oxidation by LOX via a Phosphorylase Kinase Catalytic Subunit Gamma 2 (PHKG2)-dependent iron pool is necessary for ferroptosis, and the covalent inhibition of the... WebbFerroptosis is a novel type of cell death in hepatic IRI that involves small molecules that inhibit glutathione biosynthesis or glutathione peroxidase 4 (GPX4), which is a glutathione‑dependent antioxidant enzyme, causing mitochondrial damage.
WebbCompendia expression profiles ?: GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer Institute): Advanced query: Further investigate these 64 genes : Gene families ?: Categorize these 64 genes by gene family : Show members (show 65 source identifiers mapped to 64 genes) Webb20 mars 2024 · In conclusion, PHKG2 facilitates RSL3-induced ferroptosis in H. pylori-positive GC cells by promoting ALOX5 expression. These findings may contribute to a better understanding of the unique pathogenesis of H. pylori-induced GC and allow for maximum efficacy of genetic, cellular, and immune therapies for controlling ferroptosis …
Webb10 aug. 2024 · The small molecule RSL3 has been identified as an inducer of ferroptosis and its MoA, that involves binding and inhibition of GPX4 , was recently reported (Yang et al. 2014) as determined by affinity-based proteomics. GPX4 could also be inhibited upstream as a result of the inhibition of selenoprotein (SELT), for instance by directly … Webb2 dec. 2024 · Ferroptosis is a newly discovered type of programmed cell death that, in an iron-dependent manner, peroxidizes unsaturated phospholipids and results in the …
WebbWe identified PHKG2 as a crucial regulator of ferroptosis in H. pylori-positive GC. Its expression is correlated with patient survival and ICI therapeutic response. …
Webb23 mars 2024 · In conclusion, PHKG2 facilitates RSL3-induced ferroptosis in H. pylori-positive GC cells by promoting ALOX5 expression. These findings may contribute to a … how is the world cup scoredWebb29 mars 2024 · PHKG2, IREB2, and CISD1 play an important role in ferroptosis by their function in iron metabolism balance. The phosphorylation of HSP27 induces ferroptosis resistance through blocking cytoskeleton-mediated iron absorption. EGLN1 can upregulate LSH expression by limiting HIF 1α. how is the world different todayWebb24 maj 2024 · Ferroptosis is a cell death process driven by damage to cell membranes and linked to numerous human diseases. Ferroptosis is caused by loss of activity of the key … how is the world cup organizedWebb30 apr. 2024 · Ferroptosis is an iron-dependent form of regulated cell death, which is driven by the lethal accumulation of lipid peroxidation ( 8 ). It is a novel death phenotype … how is the world divided geographicallyWebb21 mars 2024 · PHKG2 (Phosphorylase Kinase Catalytic Subunit Gamma 2) is a Protein Coding gene. Diseases associated with PHKG2 include Glycogen Storage Disease Ixc … how is the world changing todayWebb22 dec. 2024 · Phosphorylase kinase G2 (PHKG2) can regulate iron availability of lipoxygenase, including arachidonate LOX12 (ALOX12), ALOX12B, ALOX15, and … how is the world cup organisedWebb1 aug. 2024 · What is both intriguing and fascinating is the role of phosphorylase kinase G2 (PHKG2), an enzyme that induces the release of glucose-1-phosphate from glycogen, in … how is the world cup played