Stat6 regulated genes
WebNov 16, 2024 · Selective expression of constitutively activated STAT6 in intestinal epithelial cells promotes differentiation of secretory cells and protection against helminths Mucosal Immunology NB: AS...
Stat6 regulated genes
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WebJul 30, 2024 · We saw that either IL-4 or TSG6 challenge caused STAT6 binding to three sites (SB1, SB3, and SB4) in the proximal promoter region of the mGas6 gene (Fig. 2C). … WebOct 8, 2024 · Altogether, we identified a signature of STAT6-regulated genes common to MF and SS that is associated with distinct cancer-related signaling pathways. STAT6 inhibition impairs Th2 cytokine production by malignant and reactive MF/SS lymphocytes
WebThe role of STAT6-regulated gene expression in macrophages and epithelial cells in the context of helminth infections Die Rolle von STAT6-regulierten Genen in Makrophagen WebDec 5, 2011 · Introduction. STAT6 is one of the seven members of the family of transcription factors that participate in the regulation of gene expression when cells encounter various extracellular polypeptides like cytokines, hormones and growth factors and regulate a broad range of cellular processes including proliferation, differentiation and apoptosis , , , .
WebJan 19, 2024 · Additionally, STAT6 primarily regulated the expression of FAO-related genes, such as PPARα, ACOX-1, CPT-1α, rather than genes related to lipogenesis, fatty acid … WebNov 1, 2003 · Stat6-regulated genes were identified by comparing the cells isolated from the wild-type and Stat6 (-/-) mice; in this experiment the cells were induced to differentiate to the Th2 direction...
WebDec 5, 2024 · However, only 47 genes with a decent expression level were significantly regulated (36 up and 11 down). This stands in contrast to several hundred STAT6-regulated genes observed in ex vivo isolated B cells cultured for 4 days with LPS and anti-CD40 in presence or absence of IL-4 7. One possible explanation for this difference could be linked …
WebMar 3, 2024 · To confirm whether IL-13RA2 functioned through regulation of JAK/STAT6 signaling, the p-STAT6 inhibitor AS1517499 was used to treat NFb cells with IL13RA2 knockdown. As shown in Figure 6, B–D and F , AS1517499 treatment induced apoptosis and inhibited migration and invasion, while it downregulated the expression of FN1, MMP2, α … circle of blue algaeWebNov 24, 2010 · STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells Peroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). circleofblue.orgWebSTAT6 is mainly activated by cytokines interleukin-4 and interleukin-13. [5] Molecular biology [ edit] In the human genome, STAT6 protein is encoded by the STAT6 gene, located on the … circle of blood movieWebMar 21, 2024 · STRA6 (Signaling Receptor And Transporter Of Retinol STRA6) is a Protein Coding gene. Diseases associated with STRA6 include Microphthalmia, Syndromic 9 and … diamondback 701 tool vestWebSTAT6-regulated genes were identified using RNA interference (RNAi) technology and the primary target genes of STAT6 were 852 Immunity 32, 852–862, June 25, 2010 ª2010 Elsevier Inc. dissected from the downstream mediators of the signaling cascade by chromatin immunoprecipitation followed by deep diamondback 600 treadmill reviewWebThe CDKN2A locus, which contains the tumor suppressor gene p16INK4a, is associated with an increased risk of age-related inflammatory diseases, such as cardiovascular disease and type 2 diabetes, in which macrophages play a crucial role. Monocytes diamondback 6061WebCyclooxygenase-2 (COX-2) is frequently overexpressed in human cancers and contributes to the malignant phenotype. Our data indicate unphosphorylated signal transducers and activators of transcription diamondback 7.62 x 39